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Read about nexium: "Nexium capsules should be taken at least one hour before a meal. Nexium decreases the amount of acid produced in the stomach. Nexium decreases the amount of acid backing up into the esophagus and causing reflux symptoms. Nexium is a type of medicine known as an acid pump inhibitor which works by decreasing the acid produced by acid pumps. If taken on an empty stomach at least one hour before a meal."