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Celexa is the newest antidepressant to be approved by theFDA. In the treatment of depression, Celexa extends the length of time serotonin remains active in the brain. Celexa appears to be safe to use on a long-term basis and may cause less withdrawal when use is stopped. Citalopram is an antidepressant medication that affects neurotransmitters, the chemical transmitters within the brain. Depression associated with mood disorders. The manufacturer of Celexa has developed the next generation of Celexa, called Lexapro, which can treat both depression and generalized anxiety disorder. Celexa is the newest antidepressant to be approved by theFDA.