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Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. Glucophage tablets are standard release tablets that are taken two or three times a day either during or just after meals. Metformin comes as a tablet and an extended-release tablet to take by mouth. People who are overweight. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal. Metformin reduces the amount of glucose you absorb from your food and the amount of sugar produced by cells in the liver. Metformin also increases your body's proper response to the insulin you naturally produce, and by decreasing the amount of sugar in your blood.