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Celecoxib is a nonsteroidal anti-inflammatory drug that is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The breakdown of Celecoxib in the liver. In that it causes less inflammation and ulceration of the stomach and intestine and does not interfere with the clotting of blood. Celebrex works by blocking the action of a substance in the body called cyclo-oxygenase. Your normal daily activities. Celecoxib is used to treat arthritis, pain, menstrual cramps, and colonic polyps. The lowest dose possible for the shortest possible time necessary to relieve your symptoms. The pain of menstrual cramps.